Methyl N-Boc-piperidine-3-carboxylate

Methyl N-Boc-piperidine-3-carboxylate - Names and Identifiers

Name	Methyl N-Boc-piperidine-3-carboxylate
Synonyms	METHYL N-BOC-NIPECOTATE N-Boc- Piperidine-3-carboxylate N-Boc-nipecotic acid methyl ester Methyl N-Boc-piperidine-3-carboxylate Methyl 1-Boc-Piperidine-3-Carboxylate TERT-BUTYL METHYL PIPERIDINE-1,3-DICARBOXYLATE 1-TERT-BUTYL 3-METHYL PIPERIDINE-1,3-DICARBOXYLATE Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate piperidine-1,3-dicarboxylic acid O1-tert-butyl ester O3-methyl ester
CAS	148763-41-1
InChI	InChI=1/C12H21NO4/c1-12(2,3)17-11(15)13-7-5-6-9(8-13)10(14)16-4/h9H,5-8H2,1-4H3

Methyl N-Boc-piperidine-3-carboxylate - Physico-chemical Properties

Molecular Formula	C12H21NO4
Molar Mass	243.3
Density	1.094±0.06 g/cm3(Predicted)
Melting Point	47.0 to 51.0 °C
Boling Point	307.4±35.0 °C(Predicted)
Flash Point	139.7°C
Vapor Presure	0.000726mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow
pKa	-2.48±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.473
MDL	MFCD06795926

Methyl N-Boc-piperidine-3-carboxylate - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	29333990

Methyl N-Boc-piperidine-3-carboxylate - Introduction

Methyl N-Boc-piperidine-3-carboxylate is an organic compound with the chemical formula C11H19NO3. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Methyl N-Boc-piperidine-3-carboxylate is a colorless to pale yellow liquid.
-Odor: Has a special smell.
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and acetonitrile.

Use:
- Methyl N-Boc-piperidine-3-carboxylate is a commonly used organic synthesis intermediates, often used in drug synthesis.
-It can be used as a deprotection reagent for carbonyl compounds and amine compounds, and can be used to synthesize biologically active compounds.

Method:
The preparation method of Methyl N-Boc-piperidine-3-carboxylate is more complicated, and a common synthetic route is as follows:
1. First, dissolve methyl 3-piperidinecarboxylate in dimethylformamide.
2. Then, add Boc protecting reagent and corresponding base catalyst.
3. The reaction is carried out at an appropriate temperature and reaction time.
4. After the reaction, the reaction mixture can be treated by adding acid and extracting to obtain the target product.

Safety Information:
- Methyl N-Boc-piperidine-3-carboxylate may be irritating to the eyes, skin and respiratory tract. If you come into contact with this substance, rinse the affected area with plenty of water in time.
-Wear personal protective equipment such as chemical protective gloves, goggles and masks when using and handling the substance.
-should be operated in a well-ventilated place to avoid inhalation of its vapors.
-Please follow the relevant safety procedures and disposal methods to ensure the safe use of the compound.

Last Update：2024-04-09 21:01:54